Polymorph Identification and Analysis Using Ultralow-Frequency Raman Spectroscopy
■Ultralow-frequency Raman spectroscopy has commonly been cited as an effective technique for polymorph identification because it accesses the lattice vibrations related the the physical structure of the molecule.However, these frequencies have been diffcult and expensive to acces with traditional Raman spectrometer systems. Recent advances in volume holographic grating(VHG) filter technology enable rapid acquisition of high-quality ultralow-frequency Raman spectra in the 5-200 cm-1 region using a compact filter system and single-stage spectrograph, greatly simplifying and reducing the cost of utilizing this technique. We report results using this system with both visible and near infrared(NIR) excitation wavelengths to analyze multiple forms of the polymorphic active pharmaceutical ingredient carbamazepine. Both the intense low-frequency Raman bands and fingerprint region transitions are simultaneously captured and compared, demonstrating the range, ease of use, and efficacy of this technique.
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[ Polymorph ][ explosives trace ][ forensics ][ polymer ][ industrial chemical ][ manufacturing ][ cancer detection ][ basic material science ] |
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White Paper |
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Please see the document for details |
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English Chinese Chinese and English Japanese |
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June 2013 |
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646 KB |
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