Table of Contents

Introduction

Corning® Gentest™ ADME/Tox Products . . . . . . . . . . . . . . . . . . . . . . . . . 1

Corning Gentest

Contract Research Services . . . . . . . . . . . . . . . . . . . . 1

Ordering and Customer Service Contact Information . . . . . . . . . . . . . 2

Absorption/Transport

Cell Culture and Multiwell Filter Permeable Support Systems . . . .4

Corning Gentest Pre-coated PAMPA Plate System . . . . . . . . . . . . . . . . . . . . . . . 4

Corning BioCoat™ HTS Caco-2 Assay System . . . . . . . . . . . . . . . . . . . . . . . . . . . 4

Corning BioCoat Fibrillar Collagen 24 Multiwell Permeable Support System . 4

Falcon® 24 Multiwell Permeable Support System . . . . . . . . . . . . . . . . . . . . . . . 4

Companion Products for Falcon 24 Multiwell Permeable Support Systems . . . 4

HTS Transwell®-96 Well Permeable Support System . . . . . . . . . . . . . . . . . . . . 4

Falcon 96 Multiwell Permeable Support Systems . . . . . . . . . . . . . . . . . . . . . . . 5

Companion Products for Falcon 96 Multiwell Permeable Support Systems . . . 5

Transwell® Individual Cell Culture Permeable Supports . . . . . . . . . . . . . . . . . . 5

Falcon Individual Cell Culture Permeable Supports . . . . . . . . . . . . . . . . . . . . . 5

Transporter Model Systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6

Corning TransportoCells™ Cryopreserved SLC Transporter Cells . . . . . . . . . . . . 6

Corning Gentest ABC Transporter Membranes . . . . . . . . . . . . . . . . . . . . . . . . . 6

Corning Gentest ABC Transporter Vesicles . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7

Corning Gentest Transporter Kits . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7

Corning Gentest Transporter-Qualified Human CryoHepatocytes . . . . . . . . . . 7

Corning Gentest LLC-PK

Control and P-gp Expressing Cells . . . . . . . . . . . . . . . 7

Chemicals for Measuring Transporter Activity . . . . . . . . . . . . . . . . . . .7

Metabolism

Recombinant Metabolic Enzymes and Antibodies . . . . . . . . . . . . . . . . 8

Corning Supersomes™ P450/UGT Metabolic Enzymes . . . . . . . . . . . . . . . . . . 8

Controls, Cofactors, and Buffers. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11

HTS P450 Inhibition Kits . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11

Corning Gentest Human P450 Inhibition Screening Kits . . . . . . . . . . . . . . . . 11

Chemical Substrates, Inhibitors,

Metabolite Standards, and Solutions . . . . . . . . . . . . . . . . . . . . . . . . . . . 12

Stable Isotope Standards for use with Mass Spectrometry

(Listed by Enzyme) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12

Fluorescent P450 and UGT Substrates, Metabolite Standards,

and Inhibitors (Listed by Enzyme) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12

Chemical Substrates, Inhibitors, Metabolite Standards, and Solutions for

Metabolizing Enzymes (Listed by CYP Application) . . . . . . . . . . . . . . . . . . . . . 13