Luna Innovations is developing a variety of unique technologies for use in

advanced wound care and regenerative medicine.

ADVANCED WOUND HEALING

Date of Revision 8/1/2013

www.lunainc.com

706 Forest St., Suite A | Charlottesville, VA 22903

WOUND HEALING AND DRESSINGS

LUNA is committed to providing unique and advanced solutions across a range of wound healing needs. We

develop technologies for preventing postoperative adhesions, advanced dressings for ocular surface repair, and

more. Our core competencies and areas of research focus include:

 Postoperative Adhesion Barriers: Films and sprayable gels to prevent fibrous postoperative adhesions that

are an expected occurrence in all abdominal surgeries.

 Nanofiber Dressings: Ocular surface repair, advanced wound dressings, therapeutic and analgesic delivery

Post-Operative Adhesion Prevention

Postoperative adhesions are an “expected outcome” in abdominal surgeries. They are the leading cause of small-bowel

obstruction in the western world, cause chronic debilitating pain, and lead to female infertility.

LUNA’s solid barrier film applied

to an injured rat abdominal wall

Luna’s solid barrier film applied to an injured

abdominal wall

LUNA’s sprayable hydrogel applied

using a two syringe spray applicator

over a pig stomach

Nanofiber Dressings

Ocular Repair

 Dressings mimic the native ECM of the cornea and will

serve as an alternative to the standard human amniotic

membrane.

TuneCoat™ Burn Dressings

 Thin, flexible, conformable, and breathable dressings

with high mechanical strength.

 Control over analgesic and therapeutic release rate.

 Good exudate draining with bacterial invasion

prevention.

 Use alone or in conjunction with other dressings.

Barrier Film

 Low cost and simple fabrication processes

 Hydrolytically stable and robust with good

mechanical properties.

 Film is adhesive to tissue and repositionable.

 Enzymatically degradable and will resorb in vivo. The

degradation rate can be tailored

 Biocompatible and non-toxic

Sprayable Hydrogel

 Colored and flowable for easy application

 Low cost, basic materials and applicator system

 Robust to form a contiguous barrier over the

susceptible tissue surface and maintain the barrier

 Biodegradable and cleared quickly after healing

 Adhesive to tissue to maintain barrier for 4-7 days

 Biocompatible and does not impede wound healing

 Nanofiber-reinforced

hydrogels create a stimulating

environment for ocular

surface.

 PTB eliminates need for

sutures

THE TEAM

LUNA’s biomaterials and wound healing teams possess significant interdisciplinary expertise that enables us to think

outside traditional paradigms to find innovative solutions for complex medical problems. We have a diverse range of

degrees ranging from Materials Science to Synthetic Biology, and therefore are able to create unique solutions in a

multidisciplinary setting.

THE COLLABORATORS

LUNA works closely with collaborators in academia, industry, and the government. Recent collaborators include the

University of Virginia, James Madison University, University of Florida, Massachusetts General Hospital, The Wellman

Center for Photomedicine, Harvard University, and more.

REGENERATIVE MEDICINE APPLICATIONS

LUNA is positioning itself at the forefront of the regenerative medicine and tissue engineering field, developing

technologies for use in burn treatment, postoperative adhesion prevention, tissue repair, therapeutic delivery,

and cell-based therapies. Our core competencies and areas of research focus include:

 Biofunctionalized scaffolds: tissue regeneration, vascularization, cellular attachment

 Injectable hydrogels: cartilage regeneration, delivery of proteins and growth factors

 Spatially organized scaffolds: vascularized tissue, controlled tissue innervation

 Electrospinning: ocular dressings, peripheral nerve repair, wound healing, transdermal delivery

 Cell selection and delivery: vascularized tissue, proangiogenic effect

 Delipidated adipose grafts: tissue processing and plastic surgery

Date of Revision 8/1/2013

www.lunainc.com

706 Forest St., Suite A | Charlottesville, VA 22903

Christopher K. Tison, PhD |Team Lead, Biomedical Technologies|tisonc@lunainc.com|434.220.2518

Injectable Cartilage

 LUNA is exploring injectable hydrogels

for repair of craniofacial cartilage and

osteoarthritic defects.

 Hydrogels are biocompatible,

biodegradable, and stimulate cartilage

regeneration with an open porous

structure.

Bioactive Hydrogels

 Large volume tissue loss results in

functional and cosmetic defects.

 LUNA is developing 3D, bioactive

scaffolds with spatially controlled

vascularization and degradation.

 Scaffolds are being designed to fit

within current prefabricated flap

techniques.

ADVANCED WOUND HEALING